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. 2014 Oct 18;5(22):11620–11630. doi: 10.18632/oncotarget.2599

Figure 2. miR-9 expression was significantly correlated with HPV expression status.

Figure 2

(A) miR-9 expression profiles in four selected groups: HPV-negative tumors (n=14), all HPV-positive tumors (n=87), HPV16-positive tumors (n=57, with two double HPV infection cases excluded) and HPV18-positive tumors (n=15), respectively. (B) The impact of HPV E6 and E7 oncogenes on miRNA expression. HPV16 E6 or E7 genes were stably expressed in NIKS keratinocytes, and the impact on miRNA expression was determined by profiling analysis and comparison with negative control cells expressing vehicle vector. Among all miRNAs included in the analysis, four most upregulated ones are presented here. (C) Activation of miR-9 by HPV oncogenes in other cell types. HPV16 E6 or E7 were stably expressed in primary HFK keratinocytes and epithelium RPE cells, respectively, and the impact on miRNA expression was determined. miR-9 was the most activated miRNA in both HFK and RPE cells.