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. 2014 Oct 24;5(22):11452–11463. doi: 10.18632/oncotarget.2576

Figure 4. Blocking of cell surface GRP78 by anti-GRP78 antibody diminished doxorubicin and tunicamycin induction of apoptosis.

Figure 4

(A) Cell surface GRP78 in doxorubicin (d) and tunicamycin (t) treated cells was inhibited significantly by blocking of cell surface GRP78 by anti-GRP78 antibody (+ab) (*p < 0.01). No changes were observed in control cells (c). (B) Apoptosis was assessed by FACS analysis using Annexin/PI. Blocking of cell surface GRP78 (+ab) diminished apoptosis in doxorubicin (d) and tunicamycin (t) treated cells (**p < 0.008). In the upper right flank, representative FACS analysis of cell surface GRP78. Black line: Isotype, filled colored line: drug treated cells, dashed line: cell surface GRP78 blocked by anti GRP78 antibody.