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. 2014 Oct 18;5(22):11564–11575. doi: 10.18632/oncotarget.2595

Figure 1. Paclitaxel and cisplatin suppressed Id1 expression and cell viability in NSCLC cells.

Figure 1

(A) Paclitaxel suppressed Id1 expression in H520 cells in a time-dependent manner. (B) Paclitaxel suppressed Id1 expression in A549, H460, and H520 cells in a dose-dependent manner. (C) Decreased Id1 expression in vector control H460 cells (P7) and Id1-overexpressing H460 cells (O1, O4 and O12) upon treatment with paclitaxel and cisplatin. (−: no treatment, +: co-treatment with paclitaxel and cisplatin). (D) Cell viability at 48 h after co-treatment with paclitaxel and cisplatin was suppressed to a larger degree in Id1-overexpressing H460 cells (O1, O4 and O12) compared with the vector control H460 cells (P7 and P14). P was analyzed by two-sided Student's t-test. (E) Expression of p-Akt (Ser473) in Id1-overexpressing H460 cells (O4) when treated with paclitaxel and/or cisplatin.