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. 2014 Apr 30;5(22):11193–11208. doi: 10.18632/oncotarget.1933

Table 1. Statistical analysis and combination index (CI) values.

RPMI-8226 Concentration (nM) Viability Apoptosis
PPP ABT s CI S CI
125 250 ** 0.7 *** 0.63
125 500 ** 0.6 * 0.77
125 1000 * 0.6 ** 0.82
250 250 ** 0.9 *** 0.74
250 500 *** 0.8 *** 0.64
250 1000 *** 0.7 *** 0.67
500 250 ns nd ns nd
500 500 * 0.6 * 1.03
500 1000 ** 0.6 ** 1.03
OPM-2 Concentration (nM) Viability Apoptosis
PPP ABT s CI s CI
125 250 ns nd * 0.64
125 500 ns nd ** 0.61
125 1000 ns nd * 0.67
250 250 *** 0.7 * 0.78
250 500 ** 0.7 * 0.9
250 1000 ** 0.6 * 0.59
500 250 * 0.7 ns nd
500 500 * 0.6 *** 0.67
500 1000 * 0.6 *** 0.62

Significance and CI values were calculated for the different drug concentrations. Statistical significance was evaluated with a Mann-Whitney test using GraphPad Prism 5.0 software. ns = not significant, * p <0.05, ** p <0.01, *** p<0.005 when compared to both single agents. CI values were calculated by the Chou and Thalalay method using CompuSyn 1.0 software (nd = not determined, CI. 1 = synergistic).