Table 1. Statistical analysis and combination index (CI) values.
RPMI-8226 | Concentration (nM) | Viability | Apoptosis | |||
---|---|---|---|---|---|---|
PPP | ABT | s | CI | S | CI | |
125 | 250 | ** | 0.7 | *** | 0.63 | |
125 | 500 | ** | 0.6 | * | 0.77 | |
125 | 1000 | * | 0.6 | ** | 0.82 | |
250 | 250 | ** | 0.9 | *** | 0.74 | |
250 | 500 | *** | 0.8 | *** | 0.64 | |
250 | 1000 | *** | 0.7 | *** | 0.67 | |
500 | 250 | ns | nd | ns | nd | |
500 | 500 | * | 0.6 | * | 1.03 | |
500 | 1000 | ** | 0.6 | ** | 1.03 | |
OPM-2 | Concentration (nM) | Viability | Apoptosis | |||
PPP | ABT | s | CI | s | CI | |
125 | 250 | ns | nd | * | 0.64 | |
125 | 500 | ns | nd | ** | 0.61 | |
125 | 1000 | ns | nd | * | 0.67 | |
250 | 250 | *** | 0.7 | * | 0.78 | |
250 | 500 | ** | 0.7 | * | 0.9 | |
250 | 1000 | ** | 0.6 | * | 0.59 | |
500 | 250 | * | 0.7 | ns | nd | |
500 | 500 | * | 0.6 | *** | 0.67 | |
500 | 1000 | * | 0.6 | *** | 0.62 |
Significance and CI values were calculated for the different drug concentrations. Statistical significance was evaluated with a Mann-Whitney test using GraphPad Prism 5.0 software. ns = not significant, * p <0.05, ** p <0.01, *** p<0.005 when compared to both single agents. CI values were calculated by the Chou and Thalalay method using CompuSyn 1.0 software (nd = not determined, CI. 1 = synergistic).