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. 2014 Dec 10;5(22):11695–11708. doi: 10.18632/oncotarget.2586

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Copyright: © 2014 Yoon et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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(A) Telomere length decreased steadily with aging in non-cancerous gastric mucosa tissues. The fold change in telomere length was calculated by subtracting the mean Ct value of 55 non-cancerous gastric mucosae from the Ct value of each sample. (B) Telomere length in 55 gastric mucosal tissues was closely associated with GKN1 mRNA expression level. (C) Telomere length was significantly shorter in the gastric mucosal tissues with intestinal metaplasia (IM) than in cases without IM (P = 0.0014), whereas no association between telomere length and gastric mucosal atrophy was observed. (D) Telomeres shortened significantly in gastric cancer tissues, compared with those in non-cancerous gastric mucosae. (E) The GKN1 protein expression level in gastric cancer tissues was inversely correlated with telomere length. (F) An inverse association between GKN1 mRNA and c-myc and hTERT mRNA transcript expression levels, and a positive correlation between c-myc mRNA and hTERT mRNA expression were detected in gastric cancer tissues. (G) A positive correlation was observed between GKN1 and TRF1 protein expression, and an inverse association was found between c-myc with GKN1 and TRF1 protein expression in gastric cancer tissues. N, non-neoplasic gastric mucosa; T, gastric cancer.