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. 2014 Nov 19;5(22):11269–11282. doi: 10.18632/oncotarget.2579

Figure 1. Vaccinia virus replication in carcinoma A431 cells.

Figure 1

(A) Titers of the L-IVP and VVdGF-ApoS24/2 strains in the A431 cells during 72 h of in vitro incubation, and (B) in tissue of the carcinoma A431 xenografts in mice. Data are represented as a mean ± SD. (C) Active replication of the L-IVP strain and (D) apoptin-producing recombinant VVdGF-ApoS24/2 strain in cells of the carcinoma A431 xenografts, 2 days after virus injection. Boxes show C) immature and D) mature viral particles at large magnification. (E) Destruction of infected cells in xenografts on day 8 after injection of the L-IVP strain, and (F) VVdGF-ApoS24/2 strain. Arrows are pointed at lipid droplets. Boxes show damaged viral particles in cell “remains” in tumors on day 55 after the injection with E) L-IVP strain, and F) VVdGF-ApoS24/2 strain. Viral accumulations are painted with yellow color. Transmission electron microscopy, ultrathin sections.