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. 2014 Nov 19;5(22):11269–11282. doi: 10.18632/oncotarget.2579

Figure 3. Regression and histological characteristics of A431 tumors in mice after single intratumoral injection of the VACV L-IVP or VVdGF-ApoS24/2 strains.

Figure 3

Photographs of mice on day 45 after injection of: (A) saline (control), (B) L-IVP strain, and (C) VVdGF-ApoS24/2 strain. (D) Tumor growth kinetics after injection of the L-IVP and VVdGF-ApoS24/2 strains in comparison with saline-treated mice. Data are represented as a mean ± SD. (E) Representative paraffin sections of the A431 tumors at different times after single injection of saline, the L-IVP and VVdGF-ApoS24/2 strains. Note large cystic cavity in the tumor on day 8 after the L-IVP strain injection. (F) Peripheral zone and (G) central necrotic zone of the A431 tumors in mice, 2 days after the injection of saline (control group). Peripheral zones of the tumors in mice after: (H) 2 days; (I) 4 and (J) 8 days after the injection of VVdGF-ApoS24/2 strain. Swollen rounded cells were few on day 2 and increased in number on day 4 when some necrotic cells were also observed at the tumor periphery. The tumor tissue was completely destroyed on day 8 after injection, hematoxyline stained nuclei debris is seen in adjacent to capsule, which is shown by arrows. Paraffin sections, hematoxyline and eosin staining.