Table 2. Univariate and Multivariate Analyses for Disease-free survival.
Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|
Parameter | No. Case | No. Event | p-value | HR | 95% CI | p-value |
Sex | 0.4667 | |||||
Male | 177 | 43 | ||||
Female | 173 | 44 | ||||
Age (years) | 0.0584 | |||||
<70 | 259 | 59 | ||||
>=70 | 91 | 28 | ||||
Location | 0.0023b | 0.376 | ||||
Gastric | 211 | 40 | 1 | - | ||
Non-gastric | 139 | 47 | 1.257 | 0.758-2.083 | ||
Histologic Type | <0.0001b | 0.006b | ||||
Spindle | 266 | 51 | 1 | - | ||
Mixed/Epithelioid | 84 | 36 | 2.054 | 1.234-3.419 | ||
Tumor Size (cm)a | <0.0001b | |||||
=<5 cm | 161 | 16 | ||||
>5; =<10 cm | 131 | 38 | ||||
>10 cm | 58 | 33 | ||||
Mitotic Count (50HPFs)a | <0.0001b | |||||
0-5 | 249 | 33 | ||||
6-10 | 43 | 14 | ||||
>10 | 58 | 40 | ||||
NIH Consensus | <0.0001b | <0.001b | ||||
Very low/Low | 127 | 6 | 1 | - | ||
Intermediate | 110 | 17 | 4.115 | 2.164-7.812 | ||
High | 113 | 64 | 4.505 | 1.745-11.628 | ||
Mutation Type | 0.0005b | |||||
Favorable type | 106 | 22 | 1 | - | 0.047b | |
Unfavorable type | 107 | 45 | 1.702 | 1.006-2.879 | ||
AMACR gene | <0.0001b | 0.020b | ||||
Non-amplified | 281 | 34 | 1 | - | ||
Amplification | 69 | 53 | 2.005 | 1.114-3.609 | ||
AMACR expression | <0.0001b | <0.001b | ||||
Low expression | 218 | 21 | 1 | - | ||
High expression | 132 | 66 | 3.728 | 1.852-7.506 |
Tumor size and mitotic activity were not introduced in multivariate analysis, since these two parameters were component factors of NIH risk scheme;
Statistically significant. HR, hazard ratio.