Table 2. Univariate and Multivariate Analyses for Disease-free survival.

	Univariate analysis			Multivariate analysis
Parameter	No. Case	No. Event	p-value	HR	95% CI	p-value
Sex			0.4667
Male	177	43
Female	173	44
Age (years)			0.0584
<70	259	59
>=70	91	28
Location			0.0023b			0.376
Gastric	211	40		1	-
Non-gastric	139	47		1.257	0.758-2.083
Histologic Type			<0.0001b			0.006b
Spindle	266	51		1	-
Mixed/Epithelioid	84	36		2.054	1.234-3.419
Tumor Size (cm)a			<0.0001b
=<5 cm	161	16
>5; =<10 cm	131	38
>10 cm	58	33
Mitotic Count (50HPFs)a			<0.0001b
0-5	249	33
6-10	43	14
>10	58	40
NIH Consensus			<0.0001b			<0.001b
Very low/Low	127	6		1	-
Intermediate	110	17		4.115	2.164-7.812
High	113	64		4.505	1.745-11.628
Mutation Type			0.0005b
Favorable type	106	22		1	-	0.047b
Unfavorable type	107	45		1.702	1.006-2.879
AMACR gene			<0.0001b			0.020b
Non-amplified	281	34		1	-
Amplification	69	53		2.005	1.114-3.609
AMACR expression			<0.0001b			<0.001b
Low expression	218	21		1	-
High expression	132	66		3.728	1.852-7.506

^aTumor size and mitotic activity were not introduced in multivariate analysis, since these two parameters were component factors of NIH risk scheme;

^bStatistically significant. HR, hazard ratio.