Figure 2.

ISCUS clinical microdialysis analyzer measurements: at baseline (light gray bars) with plain unsupplemented perfusion fluid and during 24-hour perfusion (brain: TBI or normal) or 8-hour perfusion (muscle) with 1,2-¹³C₂ glucose (4 mmol/L; dark gray bars). LP ratio is the lactate/pyruvate ratio. *P<0.05 (Mann–Whitney) for baseline versus perfusion with 1,2-¹³C₂ glucose. Box and whisker plots represent pooled data. Numbers of patients with baseline (unsupplemented) measurements were 15 TBI, 2 ‘normal' brain, and 5 muscle. Numbers of patients who received 1,2-¹³C₂ glucose were 15 TBI, 6 ‘normal' brain, and 4 muscle. ‘Normal' brain was macroscopically normal-appearing brain in patients who underwent surgery for benign brain tumors. Muscle was leg quadriceps in patients undergoing acoustic neuroma resection surgery.