Fig. 1.

Amino acid sequence of CES1 isoform a. The first 19-amino acids, highlighted in gray, comprise the signal peptide sequence, which was omitted during cloning. Amino acids known to be associated with the biological function are boxed. Natural variants created in our experiment are underlined. The N-glycosylation site is circled, and disulfide bonds are shown by linkage of two cysteine residues.