Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Nov 21;290(2):1119–1128. doi: 10.1074/jbc.M114.619627

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 4. — Ultrastructure of spontaneously formed fibrils generated under acidic or chaotropic conditions. A, fibrils were analyzed by transmission electron microscopy using methylamine tungstate as a negative stain. No fibrils were visible using WT rPrP and acidic conditions. B and C, highly organized, linear fibrils are visible using K₄A (B) and K₄N (C) rPrP to form fibrils in acidic buffer conditions. D–F, WT (D), K₄A (E), and K₄N (F) all formed fibrils characterized by repeating twists and lateral bundling under chaotropic buffer conditions. Scale bar, 100 nm.