FIGURE 5.

Identification of distinct TF-binding sites associated with each MEF2 knockdown gene set. A, transcription factor-binding motif enrichment analysis was performed on the proximal promoter regions of each MEF2 gene set. Approximately 43% of binding motifs were shared by all four gene sets, 32% were shared by three MEF2 gene sets, 18% were shared by two MEF2 gene sets, and 7% are enriched only in genes regulated by a single MEF2 factor. B, breakdown of motif distribution by MEF2 isoform. MEF2A had the highest percentage of uniquely enriched motifs, and no unique motifs were identified for MEF2C-sensitive genes. TFBS, transcription factor binding site.