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Models of the UHRF1-TopoIIα complex for regulating the maintenance of DNA methylation. Precatenanes are formed after DNA replication fork progression, which impairs the access of DNMT1 to hemimethylated DNA. UHRF1 facilitates the access of TopoIIα to hemimethylated precatenanes. After decatenation of the precatenanes, DNMT1 can access the hemimethylated DNA and methylate the unmethylated cytosine.
