SRC inhibition with PP2 improves endothelial barrier function in Bmrp2+/− PECs.
A, TEER. TEER was evaluated 30 min after treatment with 30 μm PP2. B and C, Transwell permeability for rhodamine-70-kDa dextran (70kD-Rhod) (B) and FITC-albumin (C). Cells were treated with 30 μm PP2 for 30 min before adding fluorophore-conjugated solutes. Studies were performed in wild-type (W1) and Bmpr2+/− PECs (N6) in triplicate. Results are expressed as the mean. Error bars represent S.E. *, p < 0.05; **, p < 0.01; ***, p < 0.001 versus untreated Bmpr2+/− PECs (t test).