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IL-6/STAT3 signaling and inhibitors. Binding of IL-6 to its receptor activates Janus kinase (JAK) with subsequent phosphorylation, activation, dimerization, and nuclear translocation of STAT3. STAT3 upregulates Mcl-1 transcription. Inhibitors of IL-6, JAK, STAT3, and Mcl-1 are currently in development.
