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. Author manuscript; available in PMC: 2015 Jan 14.
Published in final edited form as: Chem Rev. 2013 Aug 6;113(11):8583–8603. doi: 10.1021/cr400105n

Figure 1. Creating a nucleosome free region for PIC formation.

Figure 1

Top, nucleosome occupancy inhibits promoter sequence recognition. Middle, occupancy of transcription factors (purple) and chromatin remodelers (pink) correlates with the nucleosome free region and promoter DNA is exposed. Bottom, GTFs, Pol II and Mediator form a PIC on the exposed promoter.