Table 1. Association between 39 SNPs from 30 loci and type 2 diabetes in the discovery stage.
| Gene region | SNPa | Alleleb | MAFc (Cases) | MAFc (Controls) | OR(95%CI) d | Pd |
|---|---|---|---|---|---|---|
| LOC64673/IRS1 | rs2943641 | C/T | 0.052 | 0.064 | 0.79(0.60,1.03) | 0.080 |
| LOC64673/IRS1 | rs7578326 | A/G | 0.133 | 0.137 | 1.03(0.87,1.23) | 0.713 |
| MRPS9/GRP45 | rs6712932 | T/C | 0.243 | 0.261 | 1.09(0.95,1.26) | 0.217 |
| BCL11A | rs243021 | A/G | 0.322 | 0.342 | 1.08(0.95,1.23) | 0.237 |
| RBMS1/ITGB6 | rs7593730 | C/T | 0.162 | 0.151 | 1.09(0.92,1.29) | 0.315 |
| IGF2BP2 | rs4402960 | G/T | 0.266 | 0.242 | 1.15(1.00,1.32) | 0.055 |
| ADAMTS9 | rs4607103 | C/T | 0.368 | 0.369 | 1.03(0.91,1.17) | 0.647 |
| LRTM1/WNT5A | rs358806 | C/A | 0.182 | 0.180 | 1.00(0.86,1.18) | 0.968 |
| ANXA5/TMEM155 | rs7659604 | C/T | 0.366 | 0.394 | 1.15(1.02,1.30) | 0.026 |
| LOC72901/CETN3 | rs12518099 | A/G | 0.447 | 0.466 | 1.07(0.95,1.21) | 0.260 |
| JAZF1 | rs864745 | T/C | 0.242 | 0.221 | 1.16(1.00,1.34) | 0.047 |
| KLF14 | rs972283 | G/A | 0.305 | 0.313 | 1.05(0.91,1.20) | 0.538 |
| SLC30A8 | rs13266634 | C/T | 0.420 | 0.471 | 1.26(1.12,1.41) | 8.32×10−5 |
| TP53INP1 | rs896854 | C/T | 0.374 | 0.414 | 1.16(1.03,1.31) | 0.016 |
| CDKN2A/CDKN2B | rs10811661 | T/C | 0.424 | 0.481 | 1.32(1.17,1.49) | 1.22×10−5 |
| CDKN2A/CDKN2B | rs564398 | T/C | 0.118 | 0.119 | 1.01(0.83,1.22) | 0.920 |
| CHCHD9 | rs13292136 | C/T | 0.080 | 0.101 | 1.34(1.08,1.65) | 7.01×10−3 |
| PTPRD | rs17584499 | C/T | 0.086 | 0.090 | 1.10(0.88,1.36) | 0.405 |
| CDC123/CAMK1D | rs10906115 | A/G | 0.354 | 0.372 | 1.07(0.94,1.22) | 0.281 |
| CDC123/CAMK1D | rs12779790 | A/G | 0.178 | 0.181 | 1.04(0.89,1.22) | 0.612 |
| KCNQ1 | rs2237897 | C/T | 0.304 | 0.380 | 1.43(1.26,1.62) | 3.45×10−8 |
| KCNQ1 | rs2237892 | C/T | 0.287 | 0.352 | 1.36(1.20,1.55) | 2.97×10−6 |
| KCNQ1 | rs2237895 | A/C | 0.341 | 0.302 | 1.19(1.05,1.36) | 7.41×10−3 |
| KCNQ1 | rs231362 | G/A | 0.107 | 0.116 | 1.11(0.92,1.35) | 0.274 |
| CENTD2 | rs1552224 | A/C | 0.079 | 0.094 | 1.39(1.12,1.73) | 2.84×10−3 |
| KCNJ11 | rs5219 | C/T | 0.407 | 0.390 | 1.09(0.96,1.24) | 0.163 |
| KCNJ11 | rs5215 | T/C | 0.406 | 0.391 | 1.09(0.96,1.23) | 0.189 |
| RPL9P23/API5 | rs9300039 | C/A | 0.244 | 0.246 | 1.03(0.89,1.18) | 0.739 |
| MTNR1B | rs1387153 | C/T | 0.421 | 0.425 | 1.02(0.90,1.15) | 0.770 |
| TSPAN8/LGR5 | rs1495377 | C/G | 0.276 | 0.269 | 1.10(0.96,1.27) | 0.156 |
| TSPAN8/LGR5 | rs7961581 | T/C | 0.210 | 0.217 | 1.03(0.88,1.19) | 0.732 |
| HMGA2 | rs1531343 | G/C | 0.142 | 0.128 | 1.12(0.94,1.34) | 0.190 |
| HIGDIC | rs12304921 | G/A | 0.489 | 0.507 | 1.07(0.95,1.20) | 0.284 |
| SPRY2 | rs1359790 | G/A | 0.258 | 0.274 | 1.12(0.971.28) | 0.111 |
| C2CD4A/C2CD4B | rs1436955 | C/T | 0.211 | 0.222 | 1.07(0.92,1.24) | 0.371 |
| C2CD4A/C2CD4B | rs7172432 | A/G | 0.365 | 0.371 | 1.00(0.88,1.13) | 1.000 |
| FTO | rs11642841 | C/A | 0.043 | 0.037 | 1.23(0.89,1.68) | 0.205 |
| SRR | rs391300 | C/T | 0.286 | 0.306 | 1.08(0.95,1.23) | 0.248 |
| HNF1B | rs4430796 | A/G | 0.308 | 0.298 | 1.07(0.93,1.21) | 0.350 |
aSingle nucleotide polymorphism (SNP).
bMajor allele/minor allele. The risk alleles are in bold.
cMinor allele frequency (MAF).
d The odds ratio (OR) with 95% confidence interval (CI) and P value were calculated for the risk allele in the additive genetic model by logistic regression with adjustment for age, sex and body mass index.