Table 2. Association between 10 suggestive SNPs and type 2 diabetes in the replication stage and combined analysis.
| Gene region | SNPa | Replication stage (Ncase/control = 1,725/2,081) | Combined analysis (Ncase/control = 2,925/3,281) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Caseb | Controlb | OR(95%CI)c | Pc | Caseb | Controlb | OR(95%CI)c | Pc | ||
| JAZF1 | rs864745 | 4.68/33.94/61.38 | 5.41/36.50/58.09 | 0.90(0.79,1.02) | 0.103 | 5.05/35.25/59.70 | 5.16/35.84/58.99 | 1.00(0.91,1.10) | 0.978 |
| SLC30A8 | rs13266634 | 15.60/50.03/34.37 | 18.38/49.16/32.47 | 1.13(1.01,1.26) | 0.027 | 35.69/46.25/18.05 | 31.64/47.75/20.61 | 1.19(1.10,1.29) | 1.43×10−5 |
| TP53INP1 | rs896854 | 12.51/43.16/44.33 | 9.84/42.24/47.93 | 0.88(0.79,0.98) | 0.025 | 13.70/43.47/42.83 | 13.34/42.65/44.02 | 0.99(0.91,1.07) | 0.801 |
| CDKN2A/CDKN2B | rs10811661 | 19.11/50.73/30.16 | 23.78/50.55/25.66 | 1.30(1.16,1.44) | 2.41×10−6 | 18.04/51.17/30.79 | 23.68/50.04/26.28 | 1.30(1.20,1.41) | 1.34×10−10 |
| CHCHD9 | rs13292136 | 0.99/17.94/81.06 | 0.96/16.09/82.95 | 0.93(0.78,1.11) | 0.411 | 0.83/16.69/82.48 | 1.13/16.51/82.35 | 1.07(0.94,1.23) | 0.302 |
| KCNQ1 | rs2237897 | 8.70/41.36/49.94 | 12.94/46.55/40.51 | 1.40(1.25,1.57) | 7.00×10−9 | 9.20/41.20/49.60 | 13.82/46.08/40.10 | 1.41(1.30,1.54) | 9.91×10−16 |
| KCNQ1 | rs2237892 | 7.95/40.15/51.90 | 11.53/43.87/44.59 | 1.35(1.20,1.51) | 4.92×10−7 | 8.07/40.50/51.43 | 12.17/43.88/43.94 | 1.35(1.24,1.47) | 9.20×10−12 |
| KCNQ1 | rs2237895 | 13.53/44.76/41.71 | 10.23/43.15/46.62 | 1.25(1.12,1.40) | 7.11×10−5 | 12.91/44.51/42.58 | 9.88/42.66/47.45 | 1.22(1.12,1.33) | 3.29×10−6 |
| CENTD2 | rs1552224 | 0.58/14.38/85.04 | 0.82/14.80/84.39 | 1.19(0.98,1.44) | 0.086 | 0.66/14.32/85.02 | 0.80/15.70/83.50 | 1.28(1.10,1.48) | 9.88×10−4 |
| ANXA5/TMEM155 | rs7659604 | 15.14/46.99/37.87 | 14.39/48.01/37.60 | 1.04(0.93,1.15) | 0.531 | 14.81/45.99/39.20 | 14.92/47.70/37.38 | 1.08(1.00,1.17) | 0.053 |
aSingle nucleotide polymorphism (SNP).
bFrequency of minor homozygote/heterozygote/major homozygote.
cThe odds ratio (OR) with 95% confidence interval (CI) and P value were calculated for the risk allele indicated in Table 1 in the additive genetic model by logistic regression with adjustment for age, sex and body mass index.