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. 2015 Jan 15;26(2):205–217. doi: 10.1091/mbc.E14-06-1049

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© 2015 Niederst et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 6: — Axonal APP vesicles colocalize with endosome markers. Immunocytochemistry of axons with (A) Rab11 and C-terminal APP Epitomics (APPE), (B) Rab5 and N-terminal A8967 (APPN), (C) Rab7 and C-terminal APP Jonas (APPJ), and (D) BACE and N-terminal APP 5a3/1g7 (APP5). Arrows indicate single-labeled APP vesicles. Arrowheads indicate double-labeled vesicles. Respective merged images are also shown. Scale bar: 5 μm. (E and F) Histogram plots of colocalization of two representative antibody pairs. Frequency of single-labeled puncta versus double-labeled puncta is plotted as a function of distribution along axon lengths.