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. 2015 Jan 15;26(2):327–338. doi: 10.1091/mbc.E14-06-1057

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© 2015 Plafker and Plafker. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Depletion of UBE2E3 reduces Nrf2 target gene expression. (A) Quantitative PCR data generated from RPE-1 cells treated with siCON (blue bars) or siUBE2E3 (red bars). Specific primers were used to amplify the Nrf2 target genes NQO1, GCLC, GCLR, and HO-1, as well as UBE2E3. (B) Same as A, except that cells were treated for 4 h with tBHQ (oxidant) before harvesting. For A and B, all samples were done in triplicate and results pooled from three independent experiments. Error bars represent ± SD, and asterisks denote statistical significance by ANOVA (p < 0.05).