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. Author manuscript; available in PMC: 2015 Jan 14.
Published in final edited form as: Fungal Genet Biol. 2013 Apr 19;60:64–73. doi: 10.1016/j.fgb.2013.04.005

Fig. 1.

Fig. 1

Blocking chitooligomers at the surface of C. neoformans altered the course of animal cryptoccocosis in favor of the host. (A) Comparison of mortality rates between animals infected with control cryptococci or with WGA-treated yeast cells revealed that the previous exposure of fungal cells to the lectin caused attenuation in the ability of C. neoformans to kill mice (n = 10). Determination of fungal burden in lungs (B) and brains (C) of infected animals (n = 5) indicated that lectin binding resulted in decreased ability to colonize the central nervous system (P = 0.0164), but not the lung (P = 0.8274). Data in A–C are representative of two independent experiments with similar results.