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Targeted therapy in gastric cancer and sites of action. VEGFR, vascular endothelial growth factor receptor; EGFR, epidermal growth factor receptor; PI3K, phosphatadylinositol 3-kinase; PTEN, phosphatase and tensin homolog; PDK-1, phosphoinositide-dependent kinase 1; Akt, protein kinase B; mTOR, mammalian target of rapamyin; HGF, hepatocyte growth factor; MEK, mitogen-activated protein/extracellular signal-regulated kinase kinase; ERK, extracellular-regulated kinase.
