Table 3. Summary of randomized trials, systematic reviews and meta-analysis comparing pre or postoperative (CT) RT with other strategies.

RCT	Number of studies	References
Postoperative CRT vs. surgery alone	2	(22,26)
Preoperative RT vs. surgery alone	4	(27-29,46)
Postoperative RT vs. postoperative CT	1	(30)
IORT vs. surgery	1	(31)
Postoperative CRT vs. postoperative CT	8	(32-39)
Systematic reviews and meta-analyses	4	(40-43)
Guidelines	1	(44)

RCT, randomised controlled trial; CRT, chemoradiotherapy; RT, radiotherapy; CT, chemotherapy; IORT, intraoperative radiotherapy.