Table 2.

Effects of drug treatment on cell cycle

Effect/drug treatment	HepG2	p53-dependence	Hep3B	References
AG490	G1 arrest	NA	Apoptosis	Kusaba et al. (2007)
Specific inhibition of hedgehog signaling	No effect	NA	Apoptosis	Huang et al. (2006)
Ganoderiol F	G1 arrest	NA	Much less effect	Chang et al. (2006)
Aloe-emodin	G1 arrest	+	Apoptosis	Kuo et al. (2002)
C75 (fatty acid synthase inhibitor)	G2 arrest	–	G1 arrest	Gao et al. (2006)
% of apoptotic cell by dengue virus infection	20 %	NA	90 %	Thongtan et al. (2004)
Silibinin	G1 arrest	NA	Both G1 and G2-M arrests	Varghese et al. (2005)
Doxorubicin	G1 arrest	NA	G2/M arrest	Lee et al. (2002a), Choi et al. (2008)
Apoptosis by Asiatic acid (AA)	Yes	NA	No	Lee et al. (2002b)
Apoptosis by TRAIL	No	NA	Yes	Ganten et al. (2004)
Apoptosis by IFN-β/LIGHT	No	NA	Yes	Li et al. (2007)
Apoptotis NK cells	No	NA	Yes	Kim et al. (2004)
Apoptosis by NS-398	No	NA	Yes	Cheng et al. (2003)
Apoptosis by INF + 5-FU	No	NA	Yes	Koike et al. (2006)
Apoptosis by Parvovirus H1	Less	NA	More	Moehler et al. (2001)
Apoptosis by anti-Fas antibody	Yes	NA	No	Lamboley et al. (2000)
Apoptosis by IFN-β	No	NA	Yes	Lamboley et al. (2000)
Apoptosis by thymidine kinase	More	NA	Less	Krohne et al. (2001)
Apoptosis by TGF-β	No	NA	Yes	Caja et al. (2011)

+: p53-dependent; –: p53-independent; NA: no direct evidence available