Table 3.
SNPs that enter stepwise regression.
| Cotinine Glucuronidation | ||||||||||
| SNP | Alt Rs# | Chr | BP | A1 | A2 | Info | Beta | P-valuea | Type | Nearest Gene |
| rs115765562 | rs34100980 | 4 | 69673553 | C | A | 1.1377 | 0.1833 | 1.60E-155 | Intergenic | UGT2B10 |
| rs141360540 | rs10028938 | 4 | 69669216 | G | A | 0.9535 | −0.1587 | 5.51E-91 | Intergenic | UGT2B10 |
| rs115219551 | rs9997650 | 4 | 69669388 | A | G | 0.8903 | −0.0941 | 1.70E-50 | Intergenic | UGT2B10 |
| rs294777 | 4 | 69682471 | A | G | 1.2244 | 0.1905 | 5.53E-48 | Intronic | UGT2B10 | |
| rs6832720 | 4 | 58148386 | A | G | 1.2635 | −0.0585 | 7.36E-09 | Intergenic | OC255130 | |
| rs1115363 | 4 | 67073143 | A | T | 0.9697 | 0.0974 | 7.38E-09 | Intergenic | LOC100144602 | |
| rs6952407 | 7 | 66045512 | A | G | 1.1719 | 0.033 | 4.51E-09 | Intergenic | LOC493754/ KCTD7 | |
| rs60634637 | 9 | 110873780 | T | C | 1.0462 | 0.0942 | 2.14E-08 | Intergenic | KLF4/ ACTL7B | |
| rs4750535 | 10 | 14633024 | C | T | 1.0947 | 0.0999 | 2.99E-10 | Intronic | FAM107B | |
| rs4287304 | 11 | 16559630 | C | T | 0.8419 | −0.1028 | 2.53E-09 | Intronic | SOX6 | |
| chr12:7996130:D | rs202090541 | 12 | 7996130 | AC | A | 0.9222 | 0.061 | 3.88E-08 | Intronic | NECAP1 / SLC2A14 |
| rs76513344 | 14 | 63047683 | C | A | 1.0516 | −0.0995 | 2.16E-09 | Intergenic | KCNH5 | |
| rs80332023 | 15 | 101073444 | C | T | 1.0749 | −0.12 | 3.35E-08 | Intronic | CERS3 / LASS3 | |
| rs60283548 | 15 | 97454880 | C | T | 1.062 | −0.1327 | 3.57E-08 | Intergenic | 7SK / SPATA8 | |
| rs34705275 | 19 | 43933725 | A | C | 1.158 | 0.0337 | 3.91E-08 | Intergenic | TEX101 / LYPD3 | |
| Nicotine Glucuronidation | ||||||||||
| SNP | Alt Rs# | Chr | BP | A1 | A2 | Info | Beta | P-valuea | Type | Nearest Gene |
| rs116224959 | rs835315 | 4 | 69685772 | G | A | 1.1326 | 0.1193 | 2.56E-43 | Intronic | UGT2B10 |
| rs4132568 | 7 | 96134981 | A | C | 1.0853 | −0.0343 | 2.69E-08 | Intronic | SHFM1 | |
a
Overall P-values were analyzed via linear regression in PLINK with adjustment for age, sex, race, principal components 1 to 10 and nicotine equivalents.