Table 4.
Determinants of cotinine and nicotine glucuronidation.
| A. Cotinine Glucuronidation | ||||
|---|---|---|---|---|
| Model: | R-square | N | Percent Variation Explained | |
| Cotinine Glucuronidation: Nicotine Equivalents | 0.0001 | 2239 | NA | |
| + Sex | 0.0005 | 2239 | 0.04% | |
| + Age | 0.0037 | 2239 | 0.32% | |
| + Race | 0.0887 | 2239 | 8.50% | |
| + Principal Components 1–10 | 0.1114 | 2239 | 2.27% | Base |
| Base Model - Cotinine Glucuronidation = Nicotine Equivalents + Sex + Age + Race + Principal Components 1–10 Data | ||||
| Base Model + 15 SNPs from Stepwise | 0.4433 | 2239 | 33.19% | Compared to Base |
| Base Model + Weighted GS with 15 SNPs from Stepwisea | 0.4246 | 2239 | 31.32% | Compared to Base |
| B. Nicotine Glucuronidation | ||||
|---|---|---|---|---|
| Model: | R-square | N | Percent Variation Explained | |
| Nicotine Glucuronidation: Nicotine Equivalents | 0.0068 | 2239 | NA | |
| + Sex | 0.0069 | 2239 | 0.01% | |
| + Age | 0.0121 | 2239 | 0.52% | |
| + Race | 0.0447 | 2239 | 3.26% | |
| + Principal Components 1–10 | 0.0513 | 2239 | 0.66% | Base |
| Base Model - Nicotine Glucuronidation = Nicotine Equivalents + Sex + Age + Race + Principal Components 1–10 Data | ||||
| Base Model + 2 SNPs from Stepwise (rs116224959 & rs4132568) | 0.1412 | 2239 | 8.99% | Compared to Base |
| Base Model + CotGluc Weighted GS with 15 SNPs from Stepwise (from Model in 4a) | 0.1365 | 2239 | 8.52% | Compared to Base |
a
The Weighted GS was weighted with the betas from the overall GWAS results.