Table 2.

Association between red meat intake, NAT2 genotype, and colorectal cancer

		Red Meat Intake
Red meat intake	Cases / Controls	Quartile 1	Quartile 2	Quartile 3	Quartile 4
Main model†	8290 / 9115	1.0	1.15 (1.06 – 1.25)	1.29 (1.19 – 1.41)	1.41 (1.29 – 1.55)
Expanded model‡	5207 / 6141	1.0	1.15 (1.03 – 1.28)	1.17 (1.05 – 1.31)	1.29 (1.15 – 1.44)
NAT2 genotype||		Slow	Intermediate / Rapid
Main model†	8290 / 9115	1.0	1.04 (0.98 – 1.11)

^†Main model adjusted for age, gender, and study site

^‡Expanded model adjusted for age, gender, study site, smoking status (ever or never), aspirin use (yes or no), NSAID use (yes or no), body mass index (in kg/m2), quartiles of dietary calcium, folate, and number of servings of fruits and vegetables per day

^||NAT2 was genotyped using rs1495741 SNP. Individuals with AA, AG, and GG genotype was classified as slow, intermediate, or rapid acetylators