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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Thromb Haemost. 2014 Dec 11;13(1):2–9. doi: 10.1111/jth.12787

Table 3.

Hazard ratios (HR) and 95% confidence intervals (CI) of total venous thromboembolism (VTE), pulmonary embolus, and deep vein thrombosis, in relation to hemoglobin S (HbS) genotype, ARIC African Americans, 1987-2011

Model Successive Adjustment Total VTE
Pulmonary Embolus*
Deep Vein Thrombosis
No S Sickle Cell
Trait
No S Sickle Cell
Trait
No S Sickle Cell
Trait
1 Age, sex, ancestry N events
Person-years
HR (95% CI)
211 67,
233
1 (Ref.)
24
4,807
1.60 (1.05-2.45)
92
65,503
1 (Ref.)
14
4,654
2.24 (1.28-3.95)
119
65,661
1 (Ref.)
10
4,566
1.18 (0.62-2.26)
2 Added HRT, BMI,
diabetes, eGFR
N events
Person-years
HR (95% CI)
205
65,621
1 (Ref.)
21
4,469
1.50 (0.96-2.36)
90
63,940
1 (Ref.)
12
4,337
2.05 (1.12-3.76)
115
64,082
1 (Ref.)
9
4,254
1.15 (0.58-2.27)
3 Add aPTT, factor VIII N events
Person-years
HR (95% CI)
201
64,101
1 (Ref.)
21
4,367
1.44 (0.92-2.27)
89
62,481
1 (Ref.)
12
4,235
2.04 (1.11-3.75)
112
62,578
1 (Ref.)
9
4,152
1.08 (0.54-2.13)
4 Full§ N events
Person-years
HR (95% CI)
199
62,582
1 (Ref.)
21
4,271
1.44 (0.91-2.27)
88
60,968
1 (Ref.)
12
4,139
2.13 (1.15-3.94)
111
61,082
1 (Ref.)
9
4,056
1.05 (0.53-2.09)
*

Pulmonary embolus with or without deep vein thrombosis.

Deep vein thrombosis without pulmonary embolus.

Numbers of events and person-years differ from Table 2 and diminish across models due to missing data on ancestry or other adjusting variables.

§

Full: Model 3 plus factor VII, von Willebrand factor, fibrinogen, protein C, and antithrombin III.

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