Table 3.
Hazard ratios (HR) and 95% confidence intervals (CI) of total venous thromboembolism (VTE), pulmonary embolus, and deep vein thrombosis, in relation to hemoglobin S (HbS) genotype, ARIC African Americans, 1987-2011
| Model | Successive Adjustment | Total VTE |
Pulmonary Embolus* |
Deep Vein Thrombosis† |
||||
|---|---|---|---|---|---|---|---|---|
| No S | Sickle Cell Trait |
No S | Sickle Cell Trait |
No S | Sickle Cell Trait |
|||
| 1 | Age, sex, ancestry | N events‡
Person-years HR (95% CI) |
211 67, 233 1 (Ref.) |
24 4,807 1.60 (1.05-2.45) |
92 65,503 1 (Ref.) |
14 4,654 2.24 (1.28-3.95) |
119 65,661 1 (Ref.) |
10 4,566 1.18 (0.62-2.26) |
| 2 | Added HRT, BMI, diabetes, eGFR |
N events Person-years HR (95% CI) |
205 65,621 1 (Ref.) |
21 4,469 1.50 (0.96-2.36) |
90 63,940 1 (Ref.) |
12 4,337 2.05 (1.12-3.76) |
115 64,082 1 (Ref.) |
9 4,254 1.15 (0.58-2.27) |
| 3 | Add aPTT, factor VIII | N events Person-years HR (95% CI) |
201 64,101 1 (Ref.) |
21 4,367 1.44 (0.92-2.27) |
89 62,481 1 (Ref.) |
12 4,235 2.04 (1.11-3.75) |
112 62,578 1 (Ref.) |
9 4,152 1.08 (0.54-2.13) |
| 4 | Full§ | N events Person-years HR (95% CI) |
199 62,582 1 (Ref.) |
21 4,271 1.44 (0.91-2.27) |
88 60,968 1 (Ref.) |
12 4,139 2.13 (1.15-3.94) |
111 61,082 1 (Ref.) |
9 4,056 1.05 (0.53-2.09) |
*
Pulmonary embolus with or without deep vein thrombosis.
†
Deep vein thrombosis without pulmonary embolus.
‡
Numbers of events and person-years differ from Table 2 and diminish across models due to missing data on ancestry or other adjusting variables.
§
Full: Model 3 plus factor VII, von Willebrand factor, fibrinogen, protein C, and antithrombin III.