Table 3B.
UGT variants nominally/significantly associated with the cotinine glucuronide ratio
| UGT SNP/Variant | European American Smokers | African American Smokers | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Alleles | MAF | Pdom | Coef (95% CI) | Alleles | MAF | Pdom | Coef (95% CI) | |||
| UGT1A4 locus | ||||||||||
| rs3732220 | C : T | .092 | C : T | ↑ | .108 | .018 | 0.50 (0.09, 0.91) | |||
| rs871514 | G : A | .478 | G : A | ↓ | .359 | .027 | −0.36 (−0.68, −0.04) | |||
| UGT1A exon 2-5 | ||||||||||
| rs1018124 | T : C | .056 | T : C | ↑ | .108 | .013a | 0.48 (0.10, 0.86) | |||
| UGT1A 3’ flanking | ||||||||||
| rs10209214 | T : C | .313 | T : C | ↓ | .142 | .023a | −0.39 (−0.72, −0.05) | |||
| UGT2B10 locus | ||||||||||
| rs61750900 (*2) | G : T | ↓ | .090 | .0004 | −0.37 (−0.56, −0.17) | G : T | .043 | |||
| rs294765 | G : A | .015 | G : A | ↓ | .217 | .017 | −0.39 (−0.71, −0.07) | |||
| rs2331559 | G : C | ↓ | .119 | .0001 | −0.36 (−0.53, −0.19) | C : G | ↑ | .362 | .006 | 0.43 (0.13, 0.74) |
| rs835309b | G : T | .106 | T : G | ↑ | .491 | .0002 | 0.66 (0.33, 0.99) | |||
| rs835310c | C : G | .023 | C : G | ↓ | .408 | .005 | −0.46 (−0.78, −0.14) | |||
| rs11726322 | G : C | ↓ | .129 | .00005 | −0.35 (−0.51, −0.19) | G : C | .254 | |||
| UGT2B7 locus | ||||||||||
| rs4356975 | C : T | ↑ | .381 | .042 | 0.17 (0.01, 0.33) | C : T | .397 | |||
a
Absence of individuals homozygous for the minor allele
b
P value not reported in European Americans as variant in high LD with rs2331559
c
Variant excluded from analyses in European Americans.
Alleles indicated as major : minor with impaired allele in bolded italics and an arrow indicating direction of effect for the minor allele. Pdom and coefficient with 95% confidence intervals from multivariate logistic regression modeling assuming a dominant effect of the minor allele and reported when P < .05. Variants ordered by location along chromosome 2 (UGT1A) and chromosome 4 (UGT2B). MAF: Minor allele frequency