Table 3D.
UGT variants nominally associated with the NNAL glucuronide ratio
| UGT SNP/Variant | European American Smokers | African American Smokers | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Alleles | MAF | Pdom | Coef (95% CI) | Alleles | MAF | Pdom | Coef (95% CI) | ||
| UGT1A1 locus | |||||||||
| rs3771342a | C : A | .112 | C : A | ↑ | .117 | .012 | 0.19 (0.04, 0.34) | ||
| UGT1A 3’ flanking | |||||||||
| rs10203853 | A : T | .431 | A : T | ↓ | .292 | .007 | −0.16 (−0.38, −0.05) | ||
| UGT2B10 locus | |||||||||
| rs835310a | C : G | .023 | C : G | ↓ | .408 | .019 | −0.15 (−0.28, −0.03) | ||
| UGT2B7 locus | |||||||||
| rs12506592 | A : G | .162 | A : G | ↓ | .275 | .030 | −0.14 (−0.26, −0.01) | ||
| rs4356975 | C : T | .381 | C : T | ↑ | .397 | .017 | 0.15 (0.03, 0.28) | ||
a
Variant excluded from analyses in European Americans.
Alleles indicated as major : minor with impaired allele in bolded italics and an arrow indicating direction of effect for the minor allele. Pdom and coefficient with 95% confidence intervals from multivariate logistic regression modeling assuming a dominant effect of the minor allele and reported when P < .05. Variants ordered by location along chromosome 2 (UGT1A) and chromosome 4 (UGT2B). MAF: Minor allele frequency