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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Naunyn Schmiedebergs Arch Pharmacol. 2014 Jul 15;388(2):199–206. doi: 10.1007/s00210-014-1010-4

Fig. 2.

Fig. 2

Potential contributions of enzymatic activities of NME1 to DNA repair pathways. Three examples of many known DNA repair pathways are represented: left, the classical non-homologous endjoining (C-NHEJ) pathway of double-strand break repair (DSBR); below center, the long and short patch pathways of base excision repair (BER); right, nucleotide excision repair (NER). Blue arrows are directed to those processes for which the NDPK activity of NME1 may contribute nucleotides to DNA polymerases through a substrate channeling mechanism, while the brown arrow represents one step in the C-NHEJ pathway at which the 3′-5′ exonuclease activity could participate.