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. Author manuscript; available in PMC: 2016 Jan 1.

Published in final edited form as: J Thromb Haemost. 2014 Nov 11;13(1):72–81. doi: 10.1111/jth.12755

Mice were immunized with either rhFVIII (A) or rpFVIII (B), respectively. Following the 7^th injection, plasma was collected via terminal cardiac puncture and assayed for inhibitor titer to the original immunogen and roFVIII via modified Bethesda assay. Lines connect the intramouse inhibitor titers recorded for the two FVIII orthologs. N = 6 and 10 respectively.

Mice were immunized with either rhFVIII (A) or rpFVIII (B), respectively. Following the 7^th injection, plasma was collected via terminal cardiac puncture and assayed for inhibitor titer to the original immunogen and roFVIII via modified Bethesda assay. Lines connect the intramouse inhibitor titers recorded for the two FVIII orthologs. N = 6 and 10 respectively.