Table 2. Association Between HPV16 Viral-load Status and HPV52 Detection Based on Retesting of Selected Cervical/Anal Specimens using HPV52 Type-specific PCR*.
HPV 16 viral load (tertiles) | HPV52+ specimens/total specimens, N | OR† (95% CI) | ||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Ludwig-McGill | McGill-Concordia | HITCH | BCCR | CCCaST | HIPVIRG | Total | All studies‡ | |
HPV 16- | 3/99 | 2/100 | 0/100 | 3/99 | 7/100 | 4/100 | 19/598 | ref |
HPV16+ | ||||||||
Low | 0/30 | 0/33 | 1/33 | 2/33 | 0/32 | 2/33 | 5/194 | 0.73 (0.24, 2.21) |
Middle | 0/30 | 1/33 | 1/33 | 0/33 | 2/32 | 7/33 | 11/194 | 1.38 (0.55, 3.45) |
High | 0/30 | 1/34 | 1/34 | 4/34 | 2/33 | 6/34 | 14/199 | 2.36 (1.08, 5.14) |
Test for heterogeneity between studies: p-value=0.52.
All specimens were HPV52 negative according to consensus primer PCR HPV DNA testing.
Adjusted for age, lifetime number of sexual partners, and study.
Some specimens from CCCaST study (n=76) were excluded from analysis because number of sexual partners information was not collected from certain subjects (St. John's study site only).