Table 2.

Brain areas that displayed metabolic changes in the acute and recovery phases and correlation with catatonic symptoms and clinical improvements

		Patient 1 (22/F)		Patient 2 (30/F)		Patient 3 (17/F)
		Initial (6 wk)	Follow-up (11 wk)	Initial (7 wk)	Follow-up (23 wk)	Initial (6 wk)	Follow-up (21 wk)
Increase PET metabolism		Rt F, T, P, Rt BG, Rt Insular, Lt BG, Lt Cbll, Lt F	Normal	Rt F, T, Rt BG, Rt Tm, Rt insular, Lt BG, Lt T	Normal	Rt T, Rt BG, Rt Tm, Rt OF, Rt Insular, Lt F, Lt BG, Lt Cbll, brainstem	Rt BG
Decreased PET metabolism		Both occipital, Lt sup. F	Normal	Both occipital, Lt F	Normal	Both occipital, Lt F, Lt angular G	Normal
Clinical symptoms	Cognitive function	Anxiety, irritability, psychotic symptoms, obey command (+)	Normal	Mute, echolalia, intermittent obey command (−)	Normal	Mute, echolalia, obey command (−)	Normal
	Motor symptom	Catatonia, Lt U/E tonic posture (Lt>Rt)	Normal	Catatonia, tonic posture rigidity (Lt>Rt), mild autonomic dysfunction	Normal	Catatonia, rigidity, tonic posture (Lt>Rt), opisthtonic posture, orofacio-tongue dyskinesia, cataplexy, autonomic dysfunction, breath abnormality	Intermittent Lt tonic rigidity
	Visual symptom	Visual hallucination	Normal	Visual hallucination	Normal	Visual hallucination	Normal

F, frontal; wk, weeks from the onset of symptoms; PET, positron-emission tomography; Rt, right; T, temporal; P, parietal; BG, basal ganglia; Lt, left; Cbll, cerebellum; Tm, thalamus; OF, orbitofrontal; sup., superior; G, gyrus; U/E, upper extremities.