Table 6.
Association between the polymorphisms and breast cancer risk according to histopathological type of patients
| Histo-pathological type* | Genotype | Cases | Controls | Odds ratio (95% confidence interval) | P |
|---|---|---|---|---|---|
| IDC | NFKB1 ins/ins | 64 | 162 | - | - |
| IDC | NFKB1 ins/del | 152 | 216 | 1.78 (1.25-2.54) | 0.002 |
| IDC | NFKB1 del/del | 130 | 123 | 2.68 (1.83-3.91) | <0.001 |
| DCIS | NFKB1 ins/ins | 12 | 162 | - | - |
| DCIS | NFKB1 ins/del | 33 | 216 | 2.06 (1.03-4.12) | 0.040 |
| DCIS | NFKB1 del/del | 26 | 123 | 2.85 (1.38-5.88) | 0.005 |
| ILC | NFKB1 ins/ins | 17 | 162 | - | - |
| ILC | NFKB1 ins/del | 25 | 216 | 1.10 (0.58-2.11) | 0.767 |
| ILC | NFKB1 del/del | 15 | 123 | 1.16 (0.56-2.42) | 0.688 |
| IDC | NFKBIA CC | 212 | 297 | - | - |
| IDC | NFKBIA CT | 102 | 162 | 0.88 (0.65-1.19) | 0.419 |
| IDC | NFKBIA TT | 32 | 42 | 1.07 (0.65-1.75) | 0.795 |
| DCIS | NFKBIA CC | 46 | 297 | - | - |
| DCIS | NFKBIA CT | 25 | 162 | 0.99 (0.59-1.68) | 0.989 |
| DCIS | NFKBIA TT | 0 | 42 | N/A | N/A |
| ILC | NFKBIA CC | 30 | 297 | - | - |
| ILC | NFKBIA CT | 20 | 162 | 1.22 (0.67-2.22) | 0.510 |
| ILC | NFKBIA TT | 7 | 42 | 1.65 (0.68-3.99) | 0.266 |
| IL-8 AA | 137 | 186 | - | - | |
| IDC | IL-8 AT | 174 | 213 | 1.10 (0.82-1.49) | 0.496 |
| IDC | IL-8 TT | 35 | 102 | 0.46 (0.29-0.72) | 0.001 |
| DCIS | IL-8 AA | 29 | 186 | - | - |
| DCIS | IL-8 AT | 33 | 213 | 0.99 (0.58-1.69) | 0.981 |
| DCIS | IL-8 TT | 9 | 102 | 0.56 (0.25-1.24) | 0.156 |
| ILC | IL-8 AA | 26 | 186 | - | - |
| ILC | IL-8 AT | 24 | 213 | 0.80 (0.44-1.45) | 0.473 |
| ILC | IL-8 TT | 7 | 102 | 0.49 (0.20-1.17) | 0.108 |
| IDC | IL-10 CC | 140 | 234 | - | - |
| IDC | IL-10 CT | 147 | 219 | 1.12 (0.83-1.50) | 0.446 |
| IDC | IL-10 TT | 59 | 48 | 2.05 (1.33-3.17) | 0.001 |
| DCIS | IL-10 CC | 29 | 234 | - | - |
| DCIS | IL-10 CT | 29 | 219 | 1.06 (0.61-1.84) | 0.812 |
| DCIS | IL-10 TT | 13 | 48 | 2.18 (1.05-4.50) | 0.034 |
| ILC | IL-10 CC | 17 | 234 | - | - |
| ILC | IL-10 CT | 22 | 219 | 1.38 (0.71-2.67) | 0.335 |
| ILC | IL-10 TT | 18 | 48 | 5.16 (2.48-10.73) | <0.001 |
| IDC | TNF c.-418 GG | 298 | 374 | - | - |
| IDC | TNF c.-418 GA | 43 | 112 | 0.48 (0.32-0.71) | 0.001 |
| IDC | TNF c.-418 AA | 5 | 15 | 0.41 (0.15-1.16) | 0.095 |
| DCIS | TNF c.-418 GG | 61 | 374 | - | - |
| DCIS | TNF c.-418 GA | 10 | 112 | 0.54 (0.27-1.10) | 0.092 |
| DCIS | TNF c.-418 AA | 0 | 15 | N/A | N/A |
| ILC | TNF c.-418 GG | 40 | 374 | - | - |
| ILC | TNF c.-418 GA | 16 | 112 | 1.33 (0.72-2.47) | 0.358 |
| ILC | TNF c.-418 AA | 1 | 15 | 0.62 (0.08-4.84) | 0.651 |
| IDC | TNF c.-488 GG | 302 | 397 | - | - |
| IDC | TNF c.-488 GA | 41 | 95 | 0.56 (0.38-0.84) | 0.005 |
| IDC | TNF c.-488 AA | 3 | 9 | 0.43 (0.11-1.63) | 0.219 |
| DCIS | TNF c.-488 GG | 61 | 397 | - | - |
| DCIS | TNF c.-488 GA | 10 | 95 | 0.68 (0.33-1.386) | 0.293 |
| DCIS | TNF c.-488 AA | 0 | 9 | N/A | N/A |
| ILC | TNF c.-488 GG | 41 | 397 | - | - |
| ILC | TNF c.-488 GA | 15 | 95 | 1.52 (0.81-2.87) | 0.188 |
| ILC | TNF c.-488 AA | 1 | 9 | 1.07 (0.13-8.70) | 0.945 |
*IDC – invasive ductal carcinoma; DCIS – ductal carcinoma in situ; ILC – invasive lobular carcinoma.