Figure 4. CpG induces IECs to produce IGF1 and induces IL-10+ Mos.
Naïve Mos were cultured with IEC in a Transwell system (IECs in the inserts; Mos in the basal chambers) at a ratio of 1:1 in the presence of CpG (the doses of PMA are denoted above each histogram). The Mos were analyzed by flow cytometry. (A–E) the histograns indicate the frequency of IL-10+ Mos. (F) the bars indicate the summarized data of the IL-10+ Mos (mean ± SD. *, p < 0.01, compared with the dose ″0″ group). Anti-IGF1 Ab = 100 ng/ml. The data represent 3 independent experiments.