Table 2.
Stillbirth Subgroup and Karyotype |
Karyotype Analysis |
Microarray Analysis | |||||
---|---|---|---|---|---|---|---|
Failed | Normal or Benign |
Probably Benign |
Variant of Unknown Significance |
Pathogenic Variant |
Aneuploidy | ||
number of stillbirths (percent) | |||||||
Antepartum (N = 443) | |||||||
Failed | 145 (32.7) | 22 (15.2) | 104 (71.7) | 0 | 10 (6.9) | 2 (1.4) | 7 (4.8) |
Normal | 269 (60.7) | 35 (13.0) | 214 (79.6) | 2 (0.7) | 13 (4.8) | 5 (1.9) | 0 |
Abnormal | 29 (6.5) | 1 (3.4) | 2 (6.9) | 0 | 1 (3.4) | 1 (3.4) | 24 (82.8) |
Intrapartum (N = 89) | |||||||
Failed | 12 (13.5) | 0 | 12 (100.0) | 0 | 0 | 0 | 0 |
Normal | 75 (84.3) | 8 (10.7) | 60 (80.0) | 2 (2.7) | 1 (1.3) | 4 (5.3) | 0 |
Abnormal | 2 (2.2) | 1 (50.0) | 0 | 0 | 0 | 0 | 1 (50.0) |
Anomalous (N = 67) | |||||||
Failed | 22 (32.8) | 3 (13.6) | 12 (54.5) | 0 | 1 (4.5) | 2 (9.1) | 4 (18.2) |
Normal | 32 (47.8) | 4 (12.5) | 25 (78.1) | 0 | 2 (6.2) | 1 (3.1) | 0 |
Abnormal | 13 (19.4) | 0 | 0 | 0 | 0 | 0 | 13 (100.0) |
Nonanomalous (N = 405) | |||||||
Failed | 122 (30.1) | 16 (13.1) | 95 (77.9) | 0 | 9 (7.4) | 0 | 2 (1.6) |
Normal | 271 (66.9) | 32 (11.8) | 218 (80.4) | 3 (1.1) | 11 (4.1) | 7 (2.6) | 0 |
Abnormal | 12 (3.0) | 1 (8.3) | 2 (16.7) | 0 | 1 (8.3) | 1 (8.3) | 7 (58.3) |
Percentages for the karyotype analysis were calculated with the number of cases in the stillbirth subgroup (antepartum, intrapartum, anomalous, or nonanomalous) as the denominator. Percentages for the microarray analysis were calculated with the number of cases in the karyotype subgroup (failed, normal, or abnormal) as the denominator. A total of 472 stillbirths underwent complete postmortem examination and were classified as either anomalous or nonanomalous. The 60 stillbirths that did not undergo complete postmortem examination were not categorized.