Table 1.
Distribution of population variables in the training and test sets by smoking and disease status
| Training set |
Test set |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Current smokers |
Former smokers |
Current smokers |
Former smokers |
||||||
| No lung cancer |
Lung cancer |
No lung cancer |
Lung cancer |
No lung cancer |
Lung cancer |
No lung cancer |
Lung cancer |
Missing (%) |
|
| Total | 73,677 (98.9) | 820 (1.1) | 77,328 (99.61) | 304 (0.39) | 8,187 (98.89) | 92 (1.11) | 8,593 (99.61) | 34 (0.39) | |
| Number of genotyped individuals, n (%) | 508 (44.8) | 626 (55.2) | 678 (74.34) | 234 (25.66) | 57 (47.9) | 62 (52.1) | 72 (72.73) | 27 (27.27) | 98.83 |
| Sociodemographic | |||||||||
| Sex, n (%) | |||||||||
| Male | 45,647 (99.23) | 354 (0.77) | 43,178 (99.76) | 104 (0.24) | 5,073 (99.24) | 39 (0.76) | 4,870 (99.75) | 12 (0.25) | 0 |
| Female | 70,169 (98.84) | 820 (1.16) | 74,009 (99.59) | 304 (0.41) | 7,774 (98.83) | 92 (1.17) | 8,225 (99.59) | 34 (0.41) | |
| Dead at censoring, n (%)a | 3,508 (100) | 0 (0) | 3,319 (100) | 0 (0) | 413 (100) | 0 (0) | 368 (100) | 0 (0) | 0 |
| Age, mean (SD), y | 57.5 (8.8) | 62 (7.3) | 60.5 (9.5) | 65.6 (8.8) | 57.4 (8.8) | 60.6 (8.2) | 60.5 (9.6) | 65.8 (8.5) | 0 |
| Age at recruitment, mean (SD), y | 49.5 (8.7) | 57.2 (7.2) | 52.5 (9.4) | 60.8 (8.4) | 49.5 (8.8) | 56.1 (8.1) | 52.5 (9.5) | 60.8 (8.3) | 0 |
| Follow-up, mean (SD), y | 7.9 (2) | 4.8 (2.6) | 8 (2) | 4.8 (2.6) | 7.9 (2) | 4.5 (2.9) | 8 (2) | 4.9 (2.3) | 0 |
| BMI, mean (SD), kg/m2 | 25.7 (4.1) | 25.7 (4.5) | 26.4 (4.1) | 26.7 (3.6) | 25.7 (4.2) | 26 (4.3) | 26.3 (4.1) | 27 (2.5) | 12.56 |
| Education, n (%) | |||||||||
| High school and below | 60,415 (98.84) | 710 (1.16) | 56,190 (99.54) | 259 (0.46) | 6,642 (98.74) | 85 (1.26) | 6,201 (99.57) | 27 (0.43) | 4.68 |
| Greater than high school | 11,817 (99.32) | 81 (0.68) | 17,532 (99.89) | 20 (0.11) | 1,390 (99.57) | 6 (0.43) | 1,984 (99.7) | 6 (0.3) | |
| Medical history | |||||||||
| Hay fever, n (%) | |||||||||
| No | 15,925 (99.1) | 145 (0.9) | 16,526 (99.73) | 45 (0.27) | 1,784 (98.84) | 21 (1.16) | 1,815 (99.78) | 4 (0.22) | 73.53 |
| Yes | 2,664 (99.48) | 14 (0.52) | 3,963 (99.67) | 13 (0.33) | 301 (99.34) | 2 (0.66) | 467 (99.57) | 2 (0.43) | |
| Asthma, n (%) | |||||||||
| No | 30,788 (99.16) | 260 (0.84) | 27,690 (99.73) | 76 (0.27) | 3,393 (99.09) | 31 (0.91) | 3,071 (99.71) | 9 (0.29) | 61.46 |
| Yes | 1,521 (98.51) | 23 (1.49) | 2,103 (98.92) | 23 (1.08) | 161 (98.17) | 3 (1.83) | 269 (99.26) | 2 (0.74) | |
| Family history of cancer, n (%) | |||||||||
| No | 9,730 (98.81) | 117 (1.19) | 10,880 (99.32) | 74 (0.68) | 1,098 (99.01) | 11 (0.99) | 1,235 (99.2) | 10 (0.8) | 84.02 |
| Yes | 1,051 (98.32) | 18 (1.68) | 1,409 (99.09) | 13 (0.91) | 121 (99.18) | 1 (0.82) | 157 (98.74) | 2 (1.26) | |
| Smoking exposures | |||||||||
| Smoking intensity, mean (SD), cpd | 13.5 (7.5) | 17.6 (7.4) | 13.1 (9.2) | 17.8 (10.9) | 13.5 (7.4) | 17.2 (7.9) | 13 (9.2) | 17.1 (11.6) | 0 |
| Smoking duration, mean (SD), y | 30.3 (9.7) | 39.5 (8.2) | 19 (10.7) | 31.4 (12.1) | 30.2 (9.8) | 38.8 (8.4) | 18.9 (10.7) | 31.7 (11) | 0 |
| Quit time, mean (SD), y | 0 (0.1) | 0 (0.1) | 15 (9.9) | 11.9 (9.3) | 0 (0.1) | 0 (0.1) | 15 (9.9) | 10.8 (7.4) | 0 |
| Age start smoking, mean (SD), y | 27.2 (6.1) | 22.5 (5.1) | 26.5 (4.8) | 22.3 (5.2) | 27.2 (6.2) | 21.8 (4.2) | 26.5 (4.9) | 23.2 (5.9) | 0 |
| Cigarettes per day | |||||||||
| ≤15 | 28,222 (98.21) | 515 (1.79) | 29,174 (99.37) | 186 (0.63) | 3,203 (98.31) | 55 (1.69) | 3,242 (99.42) | 19 (0.58) | 0 |
| >15 | 45,455 (99.33) | 305 (0.67) | 48,154 (99.76) | 118 (0.24) | 4,984 (99.26) | 37 (0.74) | 5,351 (99.72) | 15 (0.28) | |
| Occupational exposures | |||||||||
| Silica, n (%) | |||||||||
| Not exposed | 44,057 (98.64) | 609 (1.36) | 43,604 (99.51) | 216 (0.49) | 4,944 (98.58) | 71 (1.42) | 4,870 (99.47) | 26 (0.53) | 42.06 |
| Exposed | 1,125 (97.74) | 26 (2.26) | 1,153 (99.31) | 8 (0.69) | 118 (98.33) | 2 (1.67) | 104 (99.05) | 1 (0.95) | |
| PAH, n (%) | |||||||||
| Not exposed | 39,750 (98.72) | 514 (1.28) | 39,620 (99.51) | 194 (0.49) | 4,419 (98.55) | 65 (1.45) | 4,412 (99.53) | 21 (0.47) | 42.06 |
| Exposed | 5,432 (97.82) | 121 (2.18) | 5,137 (99.42) | 30 (0.58) | 643 (98.77) | 8 (1.23) | 562 (98.94) | 6 (1.06) | |
| Metal, n (%) | |||||||||
| Not exposed | 32,596 (98.65) | 447 (1.35) | 34,035 (99.56) | 150 (0.44) | 3,661 (98.79) | 45 (1.21) | 3,831 (99.56) | 17 (0.44) | 46.19 |
| Exposed | 6,827 (98) | 139 (2) | 7,521 (99.31) | 52 (0.69) | 760 (97.31) | 21 (2.69) | 806 (99.02) | 8 (0.98) | |
| Asbestos, n (%) | |||||||||
| Not exposed | 39,734 (98.73) | 513 (1.27) | 38,974 (99.54) | 182 (0.46) | 4,425 (98.75) | 56 (1.25) | 4,334 (99.54) | 20 (0.46) | 42.06 |
| Exposed | 5,448 (97.81) | 122 (2.19) | 5,783 (99.28) | 42 (0.72) | 637 (97.4) | 17 (2.6) | 640 (98.92) | 7 (1.08) | |
a
Numbers are taken at time of censoring, cases were censored at diagnosis, before death.