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. Author manuscript; available in PMC: 2015 Jan 15.
Published in final edited form as: Cancer Prev Res (Phila). 2012 Apr 11;5(6):834–846. doi: 10.1158/1940-6207.CAPR-11-0237

Table 2.

Weibull parameters and HRs of smoking intensity used in Equation (A) for the lung cancer incidence and death models for current and former smokers

Current smokers
Lung cancer incidence
Death
HR (95% CI) β1 P HR (95% CI) β2 P
Smoking intensity15 1.111 (1.084–1.139) <10−16 1.051 (1.041–1.062) <10−16

Weibull hazard parameters
Weibull hazard parameters
Strata Shape (95% CI) λ1 Scale (95% CI) γ1 Shape (95% CI) λ2 Scale (95% CI) γ2

t ≤ 18 3.819 (3.750–3.869) 0.999 (0.772–1.162) 3.690 (3.659–3.713) 1.220 (1.105–1.302)
 18 < t ≤ 20 4.056 (3.966–4.121) 1.071 (0.870–1.215) 3.774 (3.748–3.793) 1.312 (1.210–1.384)
 20 < t ≤ 22 4.230 (4.134–4.299) 1.298 (1.144–1.408) 3.859 (3.839–3.873) 1.560 (1.489–1.611)
 22 < t ≤ 24 4.339 (4.234–4.414) 1.518 (1.374–1.621) 3.944 (3.924–3.958) 1.775 (1.715–1.818)
 24 < t ≤ 26 4.380 (4.258–4.468) 1.679 (1.519–1.794) 3.979 (3.958–3.995) 1.925 (1.865–1.969)
 26 < t ≤ 28 4.567 (4.361–4.714) 1.517 (1.294–1.677) 4.049 (4.017–4.071) 1.854 (1.773–1.911)
 28 < t ≤ 30 4.506 (4.278–4.670) 1.615 (1.344–1.809) 4.096 (4.049–4.130) 1.838 (1.727–1.917)
 30 < t 4.504 (4.317–4.637) 1.684 (1.454–1.848) 4.069 (4.040–4.090) 1.912 (1.835–1.966)
Former smokers
Lung cancer incidence
Death
HR (95% CI) β1 P HR (95% CI) β2 P
Smoking intensity15 1.043 (1.012–1.076) 0.007 1.015 (1.006–1.023) <10−16

Weibull hazard parameters
Weibull hazard parameters
Strata Shape (95% CI) λ1 Scale (95% CI) γ1 Shape (95% CI) λ2 Scale (95% CI) γ2

t ≤ 22; s ≤ 20 4.987 (4.372–5.427) 0.750 (0.359–1.029) 3.754 (3.722–3.776) 1.210 (1.128–1.269)
 20 < s ≤ 30 4.723 (4.242–5.066) 0.819 (0.409–1.112) 3.750 (3.726–3.767) 1.511 (1.428–1.570)
 30 < s 4.321 (4.140–4.450) 1.032 (0.733–1.246) 3.800 (3.785–3.810) 1.669 (1.603–1.716)
 22 < t ≤ 26; s ≤ 20 5.179 (4.537–5.638) 1.165 (0.795–1.430) 4.008 (3.975–4.032) 1.621 (1.555–1.668)
 20 < s ≤ 30 4.786 (4.335–5.108) 1.353 (0.989–1.612) 3.975 (3.942–3.998) 1.742 (1.663–1.799)
 30 < s ≤ 36 4.651 (4.132–5.022) 1.460 (0.945–1.829) 3.954 (3.921–3.977) 1.835 (1.734–1.907)
 36 < s ≤ 42 4.654 (4.034–5.097) 1.318 (0.639–1.804) 3.928 (3.903–3.945) 2.129 (2.018–2.208)
 42 < s 4.366 (4.090–4.563) 1.662 (1.136–2.038) 3.982 (3.961–3.998) 2.150 (2.040–2.229)
t > 26; s ≤ 20 5.563 (4.668–6.202) 1.088 (0.640–1.409) 4.123 (4.087–4.148) 1.769 (1.698–1.820)
 20 < s ≤ 30 4.680 (4.223–5.007) 1.705 (1.249–2.032) 4.058 (4.026–4.082) 1.865 (1.781–1.926)
 30 < s ≤ 36 4.491 (4.062–4.797) 1.879 (1.312–2.283) 4.020 (3.986–4.044) 2.148 (2.027–2.234)
 36 < s ≤ 42 4.241 (3.990–4.420) 2.336 (1.754–2.751) 3.999 (3.968–4.021) 2.360 (2.213–2.465)
 42 < s 4.177 (4.052–4.266) 2.574 (2.123–2.896) 4.041 (4.007–4.066) 2.490 (2.295–2.629)

NOTE: Parameter estimates are based on maximum likelihood estimates, 95% CIs are in parentheses. Time zero set to 35 years old.

Abbreviations: s, smoking duration; t, age start smoke.