Table 2.

Representative noncoding RNAs under clinical and preclinical trials for hepatocellular carcinoma therapeutics

Target	Name	Content	Vendor	Current status
MiR34	MRX34	Liposome-formulated miR-34 mimic	Mirna Therapeutics	Phase I
VEGF/KSP	ALN-VSP	RNAi targeting VEGF/KSP	Alnylam Pharmaceuticals	Phase I
PLK1	TMK-PLK1	RNAi targeting PLK1	Tekmira Pharmaceuticals	Phase I/II
MiR21	Anti-miR21	Antisense against miR21	Regulus Therapeutics	Preclinical
MiR221	Anti-miR221	Antisense against miR221	Regulus Therapeutics	Preclinical
MiR7	MiR7 mimic	MiR7 mimic	MiReven	Preclinical

VEGF: Vascular endothelial growth factor; KSP: Kidney-specific cadherin; PLK1: Polo-like kinase 1.