Fig. 3.

Curcumin inhibits tumorigenicity of NSCLC cells in vivo. NSCLC cells were inoculated at the right flank of athymic nude mice. Mice bearing subcutaneous tumor from NSCLC cell line ACC-LC-176 (a, n = 5 in each group), H358 (b, n = 5 in each group), and A549 (c, n = 5 in each group) were treated with curcumin as soon as the tumors had reached a minimum accurately measurable size. Curcumin (50 mg/kg) or DMSO was administrated i.p. every 3 days. Mice were euthanized at the end of the experiment, and pictures of the tumor mass are presented. Tumor volume was measured every 3 days with a slide calipers from the beginning of drug treatment, and the growth curve was plotted. Tumors were weighed at the end of the experiment. Each plot presents the mean volume ± SD of 5 mice in each group. *P < 0.001