Table 2.
siRNA Targets in Aortic Aneurysm.
| Target Name | Mechanism | Study Type | Reference |
|---|---|---|---|
| IMMUNE MODULATOR | |||
| Toll-like receptors 2 and 4 (TLR2 and 4) | vascular remodeling via MMP-2 and −9 | in vitro | Cheng et al., 2011 |
| C-C chemokine receptor type 2 CCR2 | monocyte chemotaxis | mouse model | de Waard et al., 2010 |
| S100 alarmin S100A4 | SMC proliferation; remodeling via MMP | in vitro | Cao et al., 2013 |
| REACTIVE OXYGEN SPECIES | |||
| NADPH oxidase 4 (Nox4) | adventitial fibroblast activation | in vitro | Liu et al., 2012b |
| TRANSCRIPTION FACTORS | |||
| Kruppel Like Factor 4 (KLF4) | SMC differentiation | in vitro | Salmon et al., 2013 |
| MATRIX METALLOPROTEINASES (MMPs) | |||
| MMP-2 | SMC invasion | in vitro | Kimura et al., 2010 |
| MMP−9/−12 | SMC proliferation | in vitro | Dwivedi et al., 2009 |
| PROTEIN KINASES | |||
| Extracellular signal-regulated kinases 1/2 (ERK1/2) | MMP-2 formation | in vitro | Ghosh et al., 2012 |
| c-Jun NH2-terminal kinases (JNK, JNK2) | MMP activity | in vitro | DiMusto et al., 2012 |
| Protein kinase B (AKT) | MMP−2/−9 expression and secretion | in vitro | Ghosh et al., 2014 |