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. 1976 Feb;9(2):347–349. doi: 10.1128/aac.9.2.347

Synergy in the Antimicrobial Action of Penicillin and β-Chloro-d-Alanine In Vitro

Thomas S Soper 1, James M Manning 1
PMCID: PMC429525  PMID: 773296

Abstract

β-Chloro-d-alanine and penicillin G acted on early and late steps, respectively, in the biosynthesis of the bacterial cell wall. In combination these compounds showed a synergistic effect on the growth of Salmonella typhimurium and of Escherichia coli in vitro.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DAVIS B. D., MINGIOLI E. S. Mutants of Escherichia coli requiring methionine or vitamin B12. J Bacteriol. 1950 Jul;60(1):17–28. doi: 10.1128/jb.60.1.17-28.1950. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Davies M., Morgan J. R., Anand C. Interactions of carbenicillin and ticarcillin with gentamicin. Antimicrob Agents Chemother. 1975 Apr;7(4):431–434. doi: 10.1128/aac.7.4.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Glew R. H., Millering R. S., Jr, Wennersten C. Comparative synergistic activity of nafcillin, oxacillin, and methicillin in combination with gentamicin against. Antimicrob Agents Chemother. 1975 Jun;7(6):828–832. doi: 10.1128/aac.7.6.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Greenwood D., O'Grady F. Lysis enhancement: a novel form of interaction between beta-lactam antibiotics. J Med Microbiol. 1975 Feb;8(1):205–208. doi: 10.1099/00222615-8-1-205. [DOI] [PubMed] [Google Scholar]
  5. HAMILTON-MILLER J. M., SMITH J. T., KNOX R. POTENTIATION OF PENICILLIN ACTION BY INHIBITION OF PENICILLINASE. Nature. 1964 Feb 29;201:867–868. doi: 10.1038/201867a0. [DOI] [PubMed] [Google Scholar]
  6. Kaczorowski G., Shaw L., F-entes M., Walsh C. Coupling of alanine racemase and D-alanine dehydrogenase to active transport of amino acids in Escherichia coli B membrane vesicles. J Biol Chem. 1975 Apr 25;250(8):2855–2865. [PubMed] [Google Scholar]
  7. Kontomichalou P., Mitani M., Clowes R. C. Circular R-factor molecules controlling penicillinase synthesis, replicating in Escherichia coli under either relaxed or stringent control. J Bacteriol. 1970 Oct;104(1):34–44. doi: 10.1128/jb.104.1.34-44.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Manning J. M., Merrifield N. E., Jones W. M., Gotschlich E. C. Inhibition of bacterial growth by beta-chloro-D-alanine. Proc Natl Acad Sci U S A. 1974 Feb;71(2):417–421. doi: 10.1073/pnas.71.2.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Michel J., Bornstein H., Luboshitzky R., Sacks T. Mechanis of chlorampenicol-cephalordine synergism on Enerobacteiaeae. Antimicrob Agents Chemother. 1975 Jun;7(6):845–849. doi: 10.1128/aac.7.6.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. SABATH L. D., ABRAHAM E. P. SYNERGISTIC ACTION OF PENICILLINS AND CEPHALOSPORINS AGAINST PSEUDOMONAS PYOCYANEA. Nature. 1964 Dec 12;204:1066–1069. doi: 10.1038/2041066a0. [DOI] [PubMed] [Google Scholar]
  11. SUTHERLAND R., BATCHELOR F. R. SYNERGISTIC ACTIVITY OF PENICILLINS AGAINST PENICILLINASE-PRODUCING GRAM-NEGATIVE BACILLI. Nature. 1964 Feb 29;201:868–869. doi: 10.1038/201868a0. [DOI] [PubMed] [Google Scholar]
  12. Zimmermann R. A., Moellering R. C., Jr, Weinberg A. N. Mechanism of resistance to antibiotic synergism in enterococci. J Bacteriol. 1971 Mar;105(3):873–879. doi: 10.1128/jb.105.3.873-879.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]

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