Table 2.
Differences in the expression patterns of central optic cup progenitor cells (OCPCs) of wild-type, single-mutant and double-mutant eyes
| NR markers | Ciliary epithelium markers | Optic cup progenitor cell TFs | D-Cyclins (protein) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Hes5 | β-Tubulin/ Shh | Msx1 | Otx1 | BMP4 | Zic1 | Chx10 | Rax | Pax6 | CyclinD3 | CyclinD1 |
| Wild-type | expressed | expressed | absent | absent | absent | absent | expressed | expressed | expressed | absent | expressed |
| Sox2-/-; Ctnnb1-/+ | absent | absent | expressed | expressed | expressed | expressed | expressed | expressed | increased | expressed | increased |
| Sox2-/+; Ctnnb1-/- | expressed | expressed | absent | absent | absent | absent | expressed | expressed | expressed | absent | expressed |
| Sox2-/-; Ctnnb1-/- | absent | absent | absent | absent | absent | absent | expressed | expressed | increased | expressed | increased |
Abbreviation: TFs transcription factors.