Table 2.
The genotypes and allele distribution of hTERT variants in breast cancer patients and the control group
| Variants | Patients n (%) | Controls n (%) | OR (95% CI) | p |
|---|---|---|---|---|
| MNS16A Genotype | ||||
| L/L | 115 (43.2) | 66 (29.5) | 1.00 | - |
| L/S | 136(51.1) | 153(68.3) | 0.51 (0.35-0.75) | <0.001 |
| S/S | 15 (5.7) | 5 (2.2) | 1.72 (0.61-4.95) | 0.460 |
| L/S + S/S | 151 (56.8) | 158 (65.5) | 0.55 (0.38-0.81) | 0.002 |
| Allele | ||||
| L | 366 (68.8) | 285 (63.6) | 1.00 | - |
| S | 166 (31.2) | 163 (36.7) | 0.79 (0.61-1.03) | 0.090 |
| rs2736098 | ||||
| AA | 40 (15.8) | 58 (26.1) | 1.00 | - |
| AG | 140 (55.3) | 113 (50.9) | 1.80 (1.12-2.88) | 0.017 |
| GG | 72 (28.5) | 51 (23.0) | 1.80 (1.06-3.06) | 0.033 |
| AG + GG | 212 (83.8) | 164 (73.9) | 1.87 (1.19-2.94) | 0.006 |
| Allele | ||||
| A | 220 (43.7) | 229 (51.6) | 1.00 | - |
| G | 284 (56.3) | 215 (48.4) | 1.38 (1.06-1.78) | 0.016 |
| rs2735940 | ||||
| CC | 45 (17.0) | 39 (17.3) | 1.00 | - |
| CT | 124 (47.0) | 138 (61.3) | 0.78 (0.48-1.28) | 0.380 |
| TT | 95 (36.0) | 48 (21.3) | 1.72 (0.99-2.98 | 0.066 |
| CT + TT | 219 (83.0) | 186 (82.6) | 1.02 (0.64-1.64) | 0.991 |
| Allele | ||||
| C | 214 (40.5) | 216 (48.0) | 1.00 | - |
| T | 314 (59.5) | 234 (52.0) | 1.35 (1.05-1.75) | 0.020 |