Table 3.

PLS-DA classification results of HER-2 status in tumors with different ER and PgR status

	Total b/p	HER-2neg b/p	HER-2pos b/p	CV accuracy %	CV Sensitivity %	CV Specificity %	Permutation p-value
HER-2neg vs HER-2pos in ERneg	41/30	26/19	15/11	70.1	63.3	76.8	0.013
HER-2neg vs HER-2pos in ERpos	65/43	40/24	25/19	66.1	67.9	64.3	0.017
HER-2neg vs HER-2pos in PgRneg	59/42	33/24	26/18	68.8	65.3	72.3	0.006
HER-2neg vs HER-2pos in PgRpos	47/31	33/19	14/12	70.1	68.3	71.8	0.014

b = biopsies/p = patients. PLS-DA: partial least squares discriminant analysis, CV: cross validation.