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. 2014 Dec 6;14:471. doi: 10.1186/1472-6882-14-471

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© Lee et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of intrathecal injection of 5-HT antagonists on BVA-induced anti-allodynic action. The behavioral tests for cold allodynia were performed before an intrathecal injection of antagonists and after BVA treatment in the five groups of animals: (a) N/S + BV (left, n = 7) and DMSO + BV (right, n = 3), (b) NAN-190 + BV, (c) ketanserin + BV, and (d) MDL-72222 + BV (n = 8/group). Data are presented as mean ± SEM (bar graph) and individual traces in TWL change. *p < 0.05, **p < 0.01, ns = no significant, by paired t-test.