Table 1.
Definition of the RESIDUES found in the Six Tic-Oic containing analogs.
| AMP number | Residue A1 | Residue B2 | Residue C3 | Residue D4 | Residue E5 |
|---|---|---|---|---|---|
| 22 | None | None | None | None | Lys/Arg |
| 70 | None | None | None | None | Lys |
| 71 | None | None | None | None | Orn |
| 72 | None | None | None | None | Dpr |
| 73 | None | None | None | None | Dab |
| 74 | Gly | None | None | None | Lys |
| 75 | None | None | Gly | None | Lys |
| 76 | Gly | None | Gly | None | Lys |
| 77 | None | None | None | Gly | Lys |
| 78 | None | Gly | None | None | Lys |
| 79 | None | Gly | None | Gly | Lys |
| 80 | None | β-Ala | None | Gly | Lys |
(1) Residue A is the residue preceding each internal Lys residues (N-terminal side of the Lys).
(2) Residue B is the residue following each internal Lys residues (C-terminal side of the Lys).
(3) Residue C is the residue preceding each internal Phe residue (N-terminal side of the Phe).
(4) Residue D is the residue following each internal Phe residues (C-terminal side of the Phe).
(5) Residue E replaces the charged Lys residues with charged residues with progressively shorter side chains.