TABLE 1.

Functional clusters associated with the highest-score networks identified by Ingenuity pathway analysis and their scores for gene categories in FHL2-KO versus WT SMCs^a

Network	Top diseases and functions	Scoreb
1	Cell cycle, connective tissue disorders, developmental disorder	40
2	Hereditary disorder, neurological disease, lipid metabolism	36
3	Drug metabolism, molecular transport, nucleic acid metabolism	35
4	RNA posttranscriptional modification, protein synthesis, connective tissue disorders	33
5	Cellular response to therapeutics, cancer, developmental disorder	31
6	Cell cycle, cellular assembly and organization, amino acid metabolism	31
7	Cellular development, cardiovascular system development and function, hematological system development and function	31
8	Posttranslational modification, embryonic development, organ development	31
9	Skeletal and muscular system development and function, tissue development, cellular movement	30
10	Cellular movement, cellular growth and proliferation, embryonic development	30
11	Developmental disorder, hereditary disorder, neurological disease	29
12	Cellular assembly and organization, DNA replication, recombination, and repair, cell cycle	29
13	Cancer, developmental disorder, hereditary disorder	29
14	Cancer, cardiovascular disease, cellular assembly and organization	29
15	Lipid metabolism, small molecule biochemistry, vitamin and mineral metabolism	28
16	Amino acid metabolism, posttranslational modification, small molecule biochemistry	28
17	Cellular development, cellular growth and proliferation, hematological system development and function	27
18	Cell-to-cell signaling and interaction, nervous system development and function, cellular assembly and organization	26
19	Cell-to-cell signaling and interaction, cellular assembly and organization, cellular function and maintenance	26
20	Cellular function and maintenance, small molecule biochemistry, molecular transport	26
21	Embryonic development, organismal development, organ development	26
22	Cellular assembly and organization, cellular compromise, cell-to-cell signaling and interaction	26
23	Skeletal and muscular system development and function, behavior, cellular movement	26
24	Lipid metabolism, molecular transport, small molecule biochemistry	25
25	Protein synthesis, lipid metabolism, small molecule biochemistry	25

^aPathways involving cell cycle regulation are underlined, and pathways involving lipid and cholesterol metabolism are in bold.

^b−Log₁₀(P value).