Table 1.

Sensitivity and Specificity of an Algorithm to Measure Toxicity of Breast Cancer Chemotherapy During Active Treatment^* Based on Electronic Health Data From an Integrated Health Care System

Toxicity	Denominator	With Toxicity		Sensitivity		Specificity
		No.	%	%	95% CI (%)	%	95% CI (%)
Hematologic
All	99	35	35	97	84 to 99	94	86 to 98
< 65 years old	50	14	28	92	65 to 99	92	79 to 97
≥ 65 years old	49	21	43	100	84 to 100	97	83 to 99
GI (diarrhea, dehydration)
All	99	16	16	60	31 to 83	89	81 to 94
< 65	50	10	20	100	44 to 100	85	72 to 93
≥ 65	49	6	12	43	16 to 75	93	81 to 98
Infectious
All	99	13	13	73	43 to 90	94	87 to 98
< 65	50	5	10	80	38 to 96	98	88 to 100
≥ 65	49	8	16	67	30 to 90	91	78 to 96
Cardiac
All	99	10	10	60	23 to 88	93	85 to 96
< 65	50	3	6	67	21 to 94	98	89 to 100
≥ 65	49	7	14	50	9 to 91	87	75 to 94
Neuropathy
All	99	6	6	33	10 to 70	96	89 to 98
< 65	50	1	2	0	0 to 0	98	89 to 100
≥ 65	49	5	10	50	15 to 85	93	82 to 98
Mucositis
All	99	2	2	0	0 to 0	98	93 to 99
< 65	50	1	2	0	0 to 0	98	90 to 100
≥ 65	49	1	2	0	0 to 0	98	89 to 100
Nephrotoxicity
All	99	3	3	100	34 to 100	99	94 to 100
< 65	50	0	0	0	0 to 0	100	93 to 100
≥ 65	49	3	6	100	34 to 100	98	89 to 100
Hematologic/infectious/GI
All	99	48	48	92	80 to 97	80	68 to 88
< 65	50	20	40	87	62 to 96	80	64 to 90
≥ 65	49	28	57	96	80 to 99	80	61 to 91
Any toxicity
All	99	56	56	89	77 to 95†	70	57 to 81†
< 65	50	22	44	78	55 to 91	75	58 to 87
≥ 65	49	34	69	96	82 to 99	64	43 to 80

^*Active treatment is defined as the period from start of chemotherapy plus 12 months (or 24 months for those receiving Herceptin).

^†These values correspond to an area under the curve of 0.8 for a binary test.